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If no obvious improvement or if evidence of progressive fungal disease: Dose should be increased in 100 mg increments up to 200 mg orally twice a day. mefinal 500 mg obat untuk apa Maximum dose: 400 mg/day 65-mg Capsules: Loading dose: 130 mg orally 3 times a day for the first 3 days of therapy Maintenance dose: 130 mg orally once a day